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November, 2014: The UNM School of Engineering awards the Charlotte and William Kraft Graduate Fellowship to CNTC Fellow Terisse Brocato

Terisse is working with mentors Vittorio Cristini and Jeff Brinker on developing a mathematical model which is predictive of cancer treatment efficacy based on parameters measured in individuals. The award recognizes her academic excellence within the School of Engineering and provides flexible funds to enhance her professional development.

October, 2014: CNTC Trainee Amber McBride awarded the Outstanding Poster award at the 2014 NCI Cancer Nanotechnology PI meeting

Amber completed her PhD in the Nanoscience and Microsystems Engineering program in August 2014. Her primary research mentor was Pavan Muttil in Pharmacy. She will shortly move to a postdoctoral position at Sandia National Laboratories.

amber awrd

CNTC co-PI, Distinguished Professor Abhaya Datye, has been elected Fellow of the Microscopy Society of America

Professor Datye's award citation reads: "For the application of electron microscopy to better understand heterogeneous catalysts, especially catalyst preparation, sintering, regeneration, and structure–property correlations related to industrial catalytic processes."

MSA fellows are distinguished members of the society who have made significant contributions to the advancement of the science and practice of microscopy, imaging, analysis and diffraction techniques. Professor Datye is Director of the UNM Center for Microengineered Materials and was recently appointed Chair of the Department of Chemical and Biological Engineering. Read the full article

CNTC seminar Friday, September 5

CNTC trainees and mentors working at the interface of nanotechnology and imaging are encouraged to participate in the Cellular and Molecular Basis of Disease Seminar on "Role of Membrane Domains in Health and Disease" on Friday, September 5, 2014 at 12:00 in BMSB 303.

The speaker, Dr. Anne Kenworthy, from the Department of Molecular Physiology & Biophysics at Vanderbilt University School of Medicine, uses sophisticated biophysical and imaging techniques to understand the role of membrane protein complexes such as lipid rafts and caveolae in health and disease.

Congratulations to CNTC trainee Matthew Graus

Matt has just been awarded a highly competitive "Careers in Immunology" Fellowship from the American Society of Immunologists (AAI). The award will provide continued support of his work in the lab of Aaron Neumann in Pathology on the super-resolution imaging of nanoscale receptor redistributions at sites of fungal pathogen recognition by dendritic cell immunoreceptor signaling networks. Yeast infections are a significant cause of morbidity and mortality in cancer patients.

The NM CNTC welcomes a new clinician-investigator to the CNTC mentors list

picture of Rixe

Olivier Rixe, MD, PhD, has been appointed Professor in the Department of Internal Medicine, Division of Hematology/Oncology, at the University of New Mexico School of Medicine and as Associate Director for Clinical Research at the UNM Cancer Center. Professor Rixe is internationally renowned for his work in Phase I clinical trials for cancer therapy.

STC.UNM Innovation Award 2014 awarded to CNTC mentor Yubin Miao

Dr. Miao was also awarded a three year R15 grant from NCI to continue the project initiated with CNTC postdoc Jie Liu "Novel Receptor-Targeting Theranostic Peptides for Prostate Cancer".

July, 2014: Faculty Position for CNTC Postdoc Dr. Mara Steinkamp

CNTC postdoc, Mara P. Steinkamp, PhD, has been promoted to Research Assistant Professor of Pathology at UNM. Mara completed her doctoral training at the University of Michigan in the Department of Human Genetics and then came to the University of New Mexico as a CNTC postdoctoral fellow working with mentors, Bridget Wilson and Diane Lidke (Pathology) and Ashwani Rajput (Surgical Oncology). Her research focuses on ErbB signaling in cancer, using fluorescence imaging of in vitro and in vivo ovarian cancer models to examine the potential of ErbB-targeted therapies.

July 2014: Announcing the 2014 CNTC Fellows

Two postdocs and three graduate students have been awarded CNTC fellowships beginning August 1, 2014

The new CNTC postdocs are Drs. Jia Lin and Tess Shideler.

Jia is working with Aaron Neuman (Pathology) and George Bachand (CINT at Sandia National Labs) to understand the nanoscale molecular events involved in recognition of yeast by dendritic cells. New treatments that enhance immune killing of invading yeast would particularly benefit cancer patients.

Tess is working with Angela Wandinger-Ness (Pathology) and Vittorio Cristini (Pathology and Chemical Engineering) to measure amd model the ErbB1 receptor-mediated control of the endocytic transport machinery in normal and cancer cells/

The three new graduate students are Terisse Brocato (Biomedical Engineering), Kuan Feng (Biomedical Sciences) and Zahra Taghipour (Optical Sciences and Engineering).

Terisse is working with Vittorio Cristini (Pathology and Chemical Engineering) and Jeff Brinker (Chemical Engineering and Sandia National Labs) on predicitive models for cell kill by nanoparticle chemotherapy delivery for breast cancer cells in vivo".

Kuan is working with Jeremy Edwards (Chemistry and Chemical Engieering) and Keith Lidke (Physics) on next generation sequencing for cancers using super-resolution based imaging.

Zahra is working with Sanjay Kirshna, Electrical and Computer Engineering and Center for High Technology Materials on non-invasive detection of breast cancer using nano-engineered detectors

June, 2014: Dr. Vittorio Cristini among "top 1% citations" in Mathematics

Professor Vittorio Cristini, UNM Professor of Pathology and CNTC mentor, been named as one of most highly cited researchers in Mathematics by Thomson Reuters IP & Science. Dr. Cristini's recent work, involving CNTC trainees Romica Kerketta and Terisse Brocato, focuses on mathematical models that predict the in vivo delivery and release of drug-loaded nanoparticles to cancer sites in vivo. Model predictions are being tested using experimental data from the Brinker lab.

Announcing New CNTC Fellowship Support for Graduate Students and Postdocs

The New Mexico Cancer Nanotechnology Training Center (CNTC) provides stipends and interdisciplinary training to graduate students and postdocs whose interdisciplinary research uses nanoscience and nanoscience-enabled microsystems to understand the fundamental properties of cancer cells and to discover and develop diagnostic, prognostic and therapeutic tools with potential to reduce suffering and death due to cancer. Students may be enrolled in the Biomedical Sciences Graduate Program on the UNM North Campus or in any of the Physical Sciences and Engineering Programs, including NSMS and BME, on South Campus. Support will be allocated based on the academic qualifications of the student and his/her advisors, the scientific merit of the project, and the likelihood that the fellowship will work as "glue" to enhance interactions between physical and biomedical scientists working at the interface of nanoscience and cancer. Fellowship support is for one year. Graduate students receive full stipends (NIH rate) as well as tuition, fees and health insurance. Postdocs receive $25,000 towards their stipend and must demonstrate that matching funds are available to complete their full stipend. All CNTC trainees must have co-mentors, one with primary expertise in cancer biology and one with primary expertise in the physical, computational or engineering sciences.

Applications from minorities and women are encouraged. Postdocs and students who are NOT US citizens MAY apply for these fellowships. CNTC fellows may work at UNM and at partnering institutions, including the Los Alamos and Sandia National Labs.

The next CNTC application deadline is Monday June 30th for students seeking fellowship support beginning on or after August 1, 2014. For application guidelines, please see http://cntc.unm.edu/how-to-apply.html.

May 29, 2014: Science Café explores Nano Revolution

Come to the May New Mexico PBS Science Café and watch a segment of New Mexico PBS CONNECT on the development of the protocell by the Brinker team from Sandia National Labs and the UNM School of Engineering in partnership with the Willman team at the UNM Cancer Center. The presentation will be by former CNTC postdoc, Chris Lino, who is now a staff member at Sandia. Other former and current CNTC trainees involved in the project include Jason Rogers, Yu Shen Lin, Jason Townson and Paul Durfee. Protocells are novel nanoscale carriers for targeted delivery of cancer chemotherapeutic agents.

More information is at http://news.unm.edu/news/nm-pbs-science-cafe-explores-nano-revolution

April 2014: A new position for CNTC postdoc Yu-Shen Lin

Yu-Shen is moving from the Brinker group in the School of Engineering/Center for Micro-Engineered Materials to the Department of Internal Medicine in the School of Medicine. His new position is Research Assistant Professor of Medicine.

March 11, 2014: CNTC Mentor Anup Singh to talk at NMBio

Dr. Singh is Senior Manager of Biological Science and Technology at Sandia National Labs. His topic will be "Point-of-Care Diagnostic Platforms for Biodefense and Public Health Applications". All CNTC trainees are encouraged to attend. For more information visit the NMBio website.

Spring 2014 – CINT Call for User Proposals

CNTC trainees and mentors are encouraged to submit applications by March 31 for projects that can benefit from access to CINT facilities at both SNL and LANL.

Visit CINT for more information

December 12: Bioethics Course for Spring 2014

Dr. Brian Hjelle is offering a one credit problem-based discussion course on topics in bioethics such as publication credits and authorships; conflict of interest and fraud, scientific misconduct, human genomics and other relevant issues. The course will meet in Spring 2014 on Wednesdays from 1-3:15. All CNTC students may join the class. Register for CRN47577-BIOM 555 001.

December 09: Brinker Team's Protocells Move Closer to the Clinic

December 09: Dr. Mitchell H. Gold, a nationally recognized pioneer in emerging cancer-fighting therapies is now working with CNTC teams from the University of New Mexico and Sandia National Laboratories to commercialize a novel drug-delivery system that could make chemotherapy more effective while potentially eliminating toxic side effects. Gold's biotech investment firm, Alpine Biosciences, has acquired an option to license the "protocell" technology developed in the Brinker lab for targeted cancer drug delivery.

The protocell team includes CNTC mentors J. Brinker, C. Willman and W. Wharton, past trainees C. Ashley, E. Carnes and J. Townson and current trainee Y-S Lin. An article from the Dec 9 Albuquerque Journal about the acquisition is at: http://www.abqjournal.com/316517/insider/protocell-therapy-gains-potent-backer.html

View the video for this story on KOAT's website

CNTC mentors Majeed Hayat and Sanjay Krishna Named IEEE Fellows

The designation, recognized by the technical community as a prestigious honor and an important career accomplishment, is bestowed upon individuals with an outstanding record of accomplishment. The IEEE highlighted their work on the design and use of infrared detectors and focal plane arrays for the improved and non-invasive detection of skin cancer. More information is at http://news.unm.edu/news/hayat-krishna-named-ieee-fellows

November 18: Setting super-resolution microscopy images and videos to music

Flutist (and Biomedical Sciences graduate student) Tina Termini will perform a flute solo accompanied by super-resolution microscopy images and videos on Thursday November 21 at 7:30 pm in Keller Hall on UNM main campus. Tina's images are from her work in the labs of CNTC mentors Jennifer Gillette (Pathology) and Keith Lidke (Physics). Her music will be Density 21.5 by Edgar Varese. Download the flier (.jpg)

November 18: "Point of Care Technologies for Cancer"

CNTC mentors and trainees may want to attend a conference, "Point of Care Technologies for Cancer," on January 8-10, 2014 on the NIH campus in Bethesda, Maryland. The main goal of the conference, that is cosponsored by NCI and NIBIB, is to facilitate new scientific collaborations and interactions among cancer researchers and bioengineers, and to build new research programs in this important field in order to promote the translation of new technologies into clinical applications. The talks will focus on new cutting-edge point of care technologies with potential for cancer detection, diagnosis and treatment. Participants are invited to submit device demonstrations and posters. There will be a post-conference symposium on January 10 on Cancer Detection, Diagnostics and Treatment Technologies for Global Health sponsored by the NCI Center for Global Health. More information is at http://ncifrederick.cancer.gov/events/PointOfCare/register.asp

November 14, 2013: Register early for a new course on Multi-Modality Molecular Imaging and Translational Medicine beginning January 27, 2014

CNTC trainees are encouraged to register as soon as possible for a 2-credit Spring seminar course led by Dr. Yubin Mao which focuses on non-invasive molecular imaging for cancer diagnosis and treatment. The course consists of three sections: (1). Introduction of molecular imaging focusing on SPECT/PET. (2). Molecular imaging focusing on MRI, Ultrasound, Optical, Infrared and EPR. (3). The applications of different imaging modalities in the design of translational medicine for cancer. Further information is at http://cntc.unm.edu/cntc-sponsored-courses.html

January 9-11, 2014: Understanding Cell Behavior through Single Cell and Single Molecule Biology

All CNTC mentors and trainees are encouraged to attend and participate in the winter meeting January 9, 10 & 11, 2014 in Albuquerque, New Mexico co-sponsored by the CNTC, the NM Spatiotemporal Modeling Center and Sandia National Laboratories.

"Understanding Cell Behavior through Single Cell and Single Molecule Biology" is a conference in two parts.

Day one will be dedicated to a Symposium on Single Cell/Single Molecule Biology, with invited talks and contributed posters from featuring these topics:

  • Probes, imaging instruments and microfluidics devices for single cell and single molecule biology
  • New biological insights resulting from application of these new tools in immunology and cancer

Days 2 and 3 will be organized as an interactive Conference on Quantitative Bioimaging, in which tutorials to introduce key problems in Single Molecule Biology and image analysis will be followed by intense discussion and poster sessions.

Participants may register for the Symposium, the Conference or for both events. The event is free, although registration is requested and attendance will be capped at 190 participants (Symposium) and 150 participants (Conference). All participants are encouraged to submit poster abstracts aligned with one of the subject areas.

This is the third annual STMC/CNTC conference on imaging for single cell and single molecule biology. Register early and bookmark the dates for an exciting start to the new semester.

Visit the conference site to register

Download flier pdf icon

November 2013: NCI funding opportunity

NCI has re-issued PA-11-149 for R21 applications that apply nanoscience and nanotechnology approaches to address problems in cancer biology and medicine. The next deadlines are 01/07/2014, 02/16/2014 and 05/07/2014. More information is at http://grants1.nih.gov/grants/guide/pa-files/PA-11-149.html.

Contact Piotr Grodzinski for more information grodzinp@mail.nih.gov

October 24, 2013: CNTC teams receive two Outstanding and Notable Technology Awards

The Federal Laboratory Consortium recognized a team led by Sandia National Lab scientist and CNTC mentor Anup Singh for SpinDx, a lab-on-a-disk, medical diagnostic tool that can determine a patient's white blood cell count, analyze important protein markers and process up to 64 assays from a single sample, all in a matter of minutes.

The Consortium also recognized a team led by Sandia National Lab scientist and CNTC mentor Jeffrey Brinker for the development of the protocell, a novel nanoparticle delivery vehicle that can dramatically improve the efficiency of chemotherapy drugs, antibiotics and vaccines while reducing side effects.

CNTC trainees and mentors from Sandia and UNM who contributed to these awards include Carlee Ashley, Eric Carnes, Cheryl Willman, Walker Wharton, David Peabody, Jason Townson, Yu Shen Lin, Paul Durfee and Christopher Lino.

For more information see https://share.sandia.gov/news/resources/news_releases/flc_sandia/

October 01, 2013: Three new faculty added to the CNTC clinical/translational research teams and to the CNTC mentor list

All three recruits have expertise in facilitating the translation of new nanoscience approaches to cancer diagnosis and treatment across the broad range of malignant disease. Please welcome:

picture of Wadih Arap

Wadih Arap, MD, PhD

Wadih Arap, MD, PhD has joined UNM as the new Deputy Director of the UNM Cancer Center and Chief of the Division of Hematology/Oncology in the Department of Internal Medicine in the School of Medicine. He will hold the Victor and Ruby Hansen Surface Endowed Chair in Cancer Medicine.

Previously, the Stringer Professor of Medicine and Experimental Diagnostic Imaging and Deputy Chair of the Department of Genitourinary Medical Oncology in the Division of Cancer Medicine at MD Anderson Cancer Center, Dr. Arap earned his MD degree from the University of São Paulo Medical School in Brazil and completed his clinical training at Memorial Sloan-Kettering Cancer Center in New York. He earned his PhD in Cancer Biology from Stanford University and the Ludwig Institute for Cancer Research in La Jolla.

During his 14-year tenure at MD Anderson, Dr. Arap gained international recognition for his expertise in the treatment of prostate cancer. His research focused on the development of new cancer drugs and therapies that could be precisely targeted to cancer cells. His research, supported by the National Institutes of Health, the Department of Defense, and several philanthropic foundations, has led to over 60 patents worldwide and the publication of over 150 scientific studies.

picture of Renata Pasqualini

Renata Pasqualini, PhD

Renata Pasqualini, PhD, has joined UNM as the new Associate Director for Translational Research and as co-leader of the UNM Cancer Center's Program in Experimental Therapeutics and Drug Discovery. Dr. Pasqualini is Professor in the Department of Internal Medicine and holds the Maralyn S. Budke Endowed Chair in Cancer Experimental Therapeutics.

Previously the Helen Buchanan & Stanley Seeger Professor of Medicine and Experimental Diagnostic Imaging in the Division of Cancer Medicine at MD Anderson Cancer Center, she earned her PhD in Biochemistry from the Ludwig Institute for Cancer Research and the Institute of Chemistry at the University of São Paulo, Brazil. Dr. Pasqualini completed her research training at Harvard Medical School and the Dana-Farber Cancer Institute in Boston and at the Sanford-Burnham Medical Research Institute in San Diego.

During her 14-year tenure at MD Anderson, Dr. Pasqualini won international acclaim for her scientific contributions in cancer biology and drug development, especially the development of novel diagnostic and imaging tools for cancer and obesity.

picture of Martin J. Edelman

Martin J. Edelman, MD, FACP

Martin J. Edelman, MD, FACP, has joined UNM as Professor of Hematology/Oncology in the Department of Internal Medicine, Associate Director for Clinical Research at the UNM Cancer Center and co-leader of the UNM Cancer Center's Program in Lung Cancer and Aerodigestive Malignancies. Dr. Edelman will lead the New Mexico Cancer Care Alliance, a collaborative statewide cancer clinical trials network between the UNM Cancer Center and several community health-care systems. He will hold the Victor and Ruby Hansen Surface Endowed Chair in Clinical Cancer Research.

Previously Professor of Medicine, Director of the Solid Tumor Oncology, and Director of Thoracic Oncology at the University of Maryland's Greenebaum Cancer Center, Dr. Edelman earned his medical degree from The Albany Medical College and completed his clinical training at the Naval Medical Center, San Diego. Following active military service, he held faculty positions at the University of California at Davis and the VA Northern California Health Care System before joining the University of Maryland.

Mountain West Regional Chapter of the Society of Toxicology: September 19, 20

The CNTC is cosponsoring the 31st annual meeting of the Mountain West Regional Chapter of the Society of Toxicology on September 19 and 20. The theme for the 2013 meeting is Nanotoxicology. All CNTC trainees are encouraged to attend and participate. Download pdf for meeting informationpdf icon. Contact Todd Thompson (tthompson@salud.unm.edu) for further information.

CINT Call for User Proposals opens September 01, 2013

The Center for Integrated Nanotechnologies (CINT) is a Department of Energy, Office of Science Nanoscale Science Research Center jointly operated by Los Alamos and Sandia National Laboratories. As a National user facility, CINT provides access to its staff and capabilities for nanoscale science research at no fee to approved users for non-proprietary research. Proprietary research may be conducted under a full-cost recovery agreement.

Download for more details pdf icon

August 23: CNTC mentor Vittorio Cristini interviewed

August 23. Albuquerque Business First interviewed New Mexico CNTC mentor Vittorio Cristini about his work on a mathematical models to predict how much cancer chemotherapy drugs can kill in an individual patient. Read the article here

August 2013: Congratulations to CNTC Mentor Dr. Yubin Miao on his new NCI award

Dr. Miao, Assistant Professor of Pharmacy, has been awarded a 3-year NCI grant (R15CA173516) for his continued developed of "Novel Receptor-Targeting Theranostic Peptides for Prostate Cancer".

Preliminary studies leading to this award were performed in part by CNTC postdoc, Jie Liu.

Seminar, August 16, 2013: Nanoparticle Synthesis and Applications to Cancer Imaging and Treatment

Date: Friday, August 16, 2013
University of New Mexico main campus: Science & Math Learning Center Auditorium

Invited speakers
Christy Haynes, University of Minnesota, Dept of Chemistry
David Needham, Duke University, Dept of Mechanical Engineering and Materials Science
Miguel Yacaman, University of Texas San Antonio, Dept of Physics

We invite contributions from all researchers working in the area of synthesis, characterization, and applications of nanoparticles with emphasis on biomedical applications.

Contact information
Organizer: Abhaya Datye, Director Nanoscience and Microsystems Engineering

Abstracts submitted to: Heather Armstrong heathera@unm.edu, (505) 277-6824

Download poster pdf icon

Conference on Myb: Activities, Regulation and Strategies for Targeting

CNTC trainees and mentors are encouraged to register for an international meeting to be held in the UNM Cancer Center, July 22-23. The meeting is focused on the activities of and strategies for targeting Myb proteins, a family of proteins that regulate whether cells continue to proliferate or whether they differentiate into mature cells. It will include talks on multiple cancers where MYB is implicated in pathogenesis or progression as well as more general talks on technologies for therapeutic targeting of cancer-promoting proteins and genes. The meeting is supported by the Adenoid Cystic Carcinoma Research Foundation and by the UNM Cancer Center. The lead organizer is CNTC mentor, Scott Ness, from the Department of Molecular Genetics and the UNM Cancer Center.

Speakers include:

  • Lymphoid and hematopoietic cell development, stem cells, leukemia (Bender, Frampton, Look, Ness, Calabretta, Leutz)
  • Adenoid Cystic Carcinoma, breast and colon cancer, neuroblastoma (El-Naggar, Stenman, Moskaluk, Kaye, Gonda, Ramsay, Sala)
  • High throughput drug screens, targets in cancer (Wick, Sklar, Bushweller)
  • Regulation of DNA replication, cell cycle (Lipsick, Ness, Ramsay)

For more information and to register: http://cancer.unm.edu/research/international-myb-conference/

New CNTC fellows for June 01, 2013

Two postdocs and two graduate students have been awarded CNTC Fellowships beginning June 01, 2013. The postdocs are:

Matthew Lakin. Matthew is a computer scientist working with Mentors Darko Stefanovic, Computer Science and Steven Graves, Center for Biomedical Engineering on a project titled "Molecular Logic for Cancer Therapy". The goal of the project is to advance the practical implementation of DNA computing devices for the detection and treatment of cancer."

Yu-Shen Lin. Yu-Shen is a Materials Scientist with expertise in in the synthesis of small and highly biocompatible mesoporous silica nanoparticles with various functions, such as high stability, redispersibility, and low uptake by immune systems. He is working with Jeffrey Brinker, Chemical Engineering and Walker Wharton, Pathology on a project titled "Hybrid Mesoporous Silica/2D Nanosheet Nanotheranostics"

The graduate students are:

Ellen Hatch. Ellen is a MD/PhD student working with Diane Lidke, Pathology and Ashwani Rajput, Surgical Oncology on a project titled "Imaging of key regulators in colorectal cancer tumor progression: from single molecule dynamics to IHC fingerprinting using quantum dot probes."

Qi Jin. Qui is a student in the Chemistry and Chemical Biology graduate program. She is working with Fu-Sen Liang, Chemistry and Jeremy Edwards, Molecular Genetics and Chemical Engineering on a project titled "Novel Modular OncomiR Regulators"

The 36th Annual International Course on Flow Cytometry

The CNTC will cosponsor the 36th Annual International Course on Flow Cytometry, to be held in the UNM Center for Biomedical Engineering from June 8-14, 2013. This comprehensive course covers: instrumentation from basic design through performance evaluation to state-of-the-art innovations; data analysis from basic principles through advanced modeling methods; and applications in cell biology, immunology, cell signaling, fluorescent protein analysis, bead–based assays, flow imaging and high-throughput screening and sorting. Up to 6 slots have been reserved for graduate students and postdoctoral fellows to attend without charge. CNTC trainees whose research uses the advanced flow facilities at UNM and LANL for nanoparticle characterization and for the analysis of NP-cell interactions are strongly urged to contact the course lead organizer, Jim Freyer (jfreyerp@unm.edu). Information is at the 36th Annual Research Course in Flow Cytometry website

Recognition for CNTC Fellow Paul Durfee

Paul has been awarded the first George Montoya scholarship for PhD students working with mentors in the Departments of Pathology or Molecular Genetics and Microbiology. Paul is a student in the Biomedical Engineering program working between the labs of Bryce Chakerian (MGM) and Jeff Brinker (Chemical and Nuclear Engineering and Sandia National Labs) on cancer drug delivery using mesoporous silicon nanoparticles (protocells).

Announcing the 2013 CNTC Fellows

Congratulations to MD/PhD student Ellen Hatch (Pathology), PhD students Qi Jin (Chemistry) and Dominique Perez (Pathology), and to postdocs Yu Shen Lin (Chemical and Nuclear Engineering/CMEM) and Matthew Lakin (Computer Science). They were selected (out of 16 strong applicants) as new CNTC fellows beginning June 1, 2013. We look forward to having new participants in the CNTC program.

CNTC Mentor Cheryl Willman recognized with the 'La Estrella' award

In celebration of the 27th Anniversary of Women on the Move, the New Mexico YWCA announced that Dr. Cheryl Willman will be honored with the "La Estrella" award. The award was presented recently along with the other Women on the Move awards at an event held at the National Hispanic Cultural Center. Dr. Willman is Director and CEO of the UNM Cancer Center, PI (with J. Brinker) of the UNM CNPP grant and a mentor in the CNTC.

Read more at UNM Today

CNTC mentor Alan Tomkinson uses abnormal DNA repair to selectively target cancer cells

Developing cancer therapies that have minimal side-effects depends upon finding and killing only the cancer cells, leaving the healthy cells alone. To selectively kill cancer cells, a cross-institution team of researchers has developed a technique that targets cancer cells' abnormal DNA repair machinery. One member of that team is CNTC mentor Alan Tomkinson. Dr. Tomkinson is UNM Professor of Internal Medicine and associate director of Basic Research at the UNM Cancer Center.

Read more at UNM Today

CNTC Mentor Sanjay Krishna Receives Awards

Sanjay Krishna, Professor of Electrical and Computer Engineering and Regents' Lecturer, will be presented with the Young Scientist Award for 2013 from the International Symposium of Compound Semiconductors at their meeting in Kobe, Japan in May. The award, which was established in 1986, acknowledges technical achievements in the field of compound semiconductors by a scientist under 40 years old. Krishna will also receive a BizTech Innovation Award from Albuquerque Business First for his company SKINfrared. Read more in UNM Today

Nano Day is April 06

The CNTC's annual Art of Systems Biology and Nanoscience event March 29 and 30 in Santa Fe attracted record crowds of artists, scientists as well as more than 100 kids interested in nanoscience. Anyone who missed the event is cordially invited to come (with or without kids) to the New Mexico Museum of Natural History this coming Saturday April 6 from 10-2. The CNTC graduate students will repeat their hands-on Nanodays program and selected pieces from the art show will be displayed. Information about the follow-on event is at http://www.nmnaturalhistory.org/nano-day.html

The 2013 Art of Systems Biology and Nanoscience in the news

See great March 27th features on this show by Santa Fe Reporter and the UNM Cancer Center:

2013 Nano After School Camp field trip to UNM

CINT Call for User Proposals, Spring 2013

User Proposal Submission: https://cint.sandia.gov/
Website available: March 1, 2013
Submission Deadline: March 31, 2013

The Center for Integrated Nanotechnologies (CINT) is a Department of Energy, Office of Science Nanoscale Science Research Center jointly operated by Los Alamos and Sandia National Laboratories. As a National user facility, CINT provides access to its staff and capabilities for nanoscale science research at no fee to approved users for non-proprietary research. Proprietary research may be conducted under a full-cost recovery agreement.

Huffington Post recognizes work by CNTC scientists.

February 21, 2013. The Brinker team, including CNTC postdoc Jason Townson, was recognized in the Huffington Post for its recent work on the creation of silica replicas of cancer cells. The description at The Huffington Post suggests a sci-fi twist to the work, that was reported in the October 08, 2012 issue of Proceedings of the National Academy of Sciences.

Nanomedicine for Imaging and Treatment Conference

Please take note of an upcoming nanomedicine conference: the 2nd Nanomedicine for Imaging and Treatment Conference. This meeting will take place in Los Angeles, CA at Cedars-Sinai Medical Center on March 15-16, 2013.

Topics include:

  • Recent achievements in drug delivery
  • Nanomedicine and Imaging
  • Role of NIH in nanodrug development
  • Latest preclinical and clinical advances in the treatment of cancer, neurodegenerative disorders, and other pathological conditions.

Additional details can be found in the attached brochure and at http://nanomedtech.org/.

CNTC welcomes a new trainee, Romika Kerketta

picture of Romika Kerketta

Romika Kerketta is a second year Biomedical Sciences graduate student working with Professor Vittorio Cristini (Pathology and Chemical Engineering) on the modeling of nanoparticle-mediated drug delivery to human colorectal liver metastases.

Announcing the first new CNTC Fellow for 2013

picture of Christopher Lino

Christopher Lino was appointed a CNTC fellow beginning January 1. 2013.

Chris is working with Drs. David Peabody (Molecular Genetics) and Carlee Ashley (Sandia) on a project titled DISPLAY OF SINGLE-CHAIN ANTIBODY LIBRARIES ON BACTERIOPHAGE MS2 VIRUS-LIKE PARTICLES. The goal of the project is to use technology pioneered in the Peabody lab to produce a new virus-like particle (VLP) display system for libraries of single-chain antibodies (scFvs). By screening cancer cell ligands or receptors against such a library, Lino hopes to develop novel scFvs for a particular target. Further usefulness is provided by the VLP itself. Because the scFv-displaying VLP is hollow, it can be loaded with various types of cargo, including cytotoxic drugs and then be targeted with high affinity and specificity to cancer cells for drug delivery.

The 2013 NCI Alliance Calendar will showcase the beauty of UNM's nanoparticles

ovo chick
The image of fluorescent protocells circulating in the vasculature of ex ovo chick embryos was taken by Jason Townson, a recent CNTC postdoc in the Brinker team.

2013 Gordon Research Conference on Cancer Nanotechnology

The second Gordon Research Conference on Cancer Nanotechnology is scheduled for July 14-19, 2013 in Vermont. A preliminary schedule and links for further information about program and funding can be found here.

UNM science featured in 2012 NCI Alliance for Cancer Nanotechnology Bulletin

UNM science is featured in the 2012 NCI Alliance for Cancer Nanotechnology Bulletin. View the Bulletin for details pdf icon.

Pharmacy 580 Toxicology

All CNTC trainees are encouraged to signup for the Toxicology graduate course that will be offered in Spring 2013. View course details pdf icon.

Recognition for CNTC mentor Bridget Wilson

CNTC mentor Bridget Wilson, PhD was recently elected a Fellow to the American Association for the Advancement of Science. Dr. Wilson is Professor of Pathology and also serves as one of four program leaders in UNM's National Cancer Institute (NCI)-designated Cancer Center. Fellows are recognized for meritorious efforts to advance science or its applications.

Dr. Wilson also received the 2012 Award in Basic Science Research at the Health Sciences Center's 4th Annual Research Day on Friday, October 26, 2012.

New appointment for CNTC postdoc David Ramirez

david ramirez

David Ramirez received his PhD in Electrical Engineering in 2011 and was a CNTC postdoc in 2012 working with CNTC mentor Sanjay Krishna on the use of nanotechnology-based thermal imaging for early diagnosis of skin cancer. Congratulations to David for his new position as staff scientist in Professor Krishna's company, SKINfrared.

CNTC postdoc Jason Townson in UNM Today

photo of ryan and jason
Bryon Kaehr, left, and Jason Townson.

The November 2012 issue of UNM Today featured CNTC postdoc Jason Townson in an article entitled "The Friday Afternoon Breakthrough". Download the article here pdf icon.

CNTC postdoc Robert Taylor moving to the Gullapalli lab

Ramachandra (Rama) Gullapalli, MD/PhD, an expert in clinical molecular diagnostics and in nano/microscale engineering for medical diagnostic devices, joined the UNM faculty in Pathology and Biomedical Engineering in September 2012. Robert Taylor completed his PhD and a brief postdoc as a CNTC fellow with Laurel Sillerud and Marco Bisoffi, working on blood brain barrier permeable, multi-targeted, multifunctional, iron platinum, crosslinked-stealth immunomicelles.

We congratulate Robert on his move to the Gullapalli lab and look forward to the emergence of a productive new team in cancer nanotechnology. We also congratulate Robert on his new funding through the Academic Science Education and Research Training (ASERT) program. Led by Angela Wandinger-Ness, ASERT Fellows receive three years of funding through the NIGMS IRACDA program and spend 25% time on educational enrichment and teaching at partner minority-serving institutions across New Mexico and 75% time on cutting edge research.

November 01: Women in Technology Awards to CNTC Mentors Wandinger-Ness and Willman

CNTC mentors Dr. Angela Wandinger-Ness (Yuna Guo) and Dr. Cheryl Willman (Jason Rogers) both received Women in Technology awards from the New Mexico Technology Council. Wandinger-Ness was recognized for her applications of flow cytometry, imaging and nanotechnology to discover drugs targeting Ras-related GTPases. Willman, who is PI with J. Brinker of a Cancer Nanotechnology Platform Partnership for NP-mediated drug delivery, was recognized for her seminal research efforts that have advanced our understanding and treat­ment of blood cancers. More information is at http://news.unm.edu/?p=33290

Images from The Art of Systems Biology and Nanoscience will be featured at the Annual meeting of the American Society for Cell Biology

Attendees at the December 2012 ASCB meeting in San Francisco will enjoy a gallery of large format prints of molecular and cellular images spread over two open spaces in the Moscone Center. In an article in the October 2012 ASCB Newsletter, the CNTC-sponsored Art of Systems Biology and Nanoscience event in Santa Fe is recognized as the inspiration for the event as well as the source of the large format illustrations by Graham Johnson, our 2012 Artist-in-Residence. The article emphasizes the ability of art to make science more accessible and understandable for both scientists and the public. We are thrilled that our outreach event has expanded its reach and hope that ASCB and other national and international organizations will want to take images from future Art of Systems Biology and Nanoscience "on the road".
View the October 2012 ASCB Newsletter segment pdf icon

The ASME 2013 2nd Global Congress on Nanoengineering for Medicine and Biology (NEMB)

The ASME 2013 2nd Global Congress on Nanoengineering for Medicine and Biology (NEMB) will be held from February 4-6, 2013 in Boston, MA.

The Alliance for Nanotechnology in Cancer is organizing two sessions:

1. "Bioresponsive materials for imaging, diagnostics, and therapeutics"
Description: The body is a dynamic system whereby disease states show differences in physiology, gene expression, and signaling pathways. Researchers are developing novel reagents that are able to utilize and/or measure dynamic states for use in detection, monitoring, and treating disease. For example, bioactivatable imaging probes can detect biomarkers in vivo, and engineered delivery platforms can utilize physiological pathways to aid in drug delivery. This session will highlight how engineered materials can be utilized for imaging, diagnostics, and therapeutic strategies.

2. "Materials and devices for quantitative biomarker detection and single cell analysis"
Description: Cancer is a disease whereby a single tumor may be very heterogenous in nature and spawn circulating tumor cells which may eventually give rise to secondary tumors. Researchers are developing materials and devices capable of measuring biomarkers at low levels for early detection of disease and/or metastasis. Additionally, devices and assays that measure single cell parameters reveal information about single cells within a population. This session will highlight how engineered materials and devices can be utilized for single cell analysis and quantitative biomarker detection.

More information can be found at http://www.asmeconferences.org/NEMB2013/index.cfm

CNTC mentors and trainees are encouraged to submit abstracts (due October 15). CNTC trainees may request partial travel support.

CNTC Trainees - Please Mark your Calendars (and Submit Abstracts) for the Second Annual CBME/NSMS Student-led Symposium on November 16

We want you! Because of the interdisciplinary nature of the NSMS and BME programs, we all come from a diverse range of scientific disciplines and are divided across the UNM campus (including Sandia and Los Alamos). As a result, we do not always have the opportunity to share our research with one another.

In an effort to create awareness within the programs and foster a more collaborative environment we, as your NSMS and BME GSA, are planning to put on a student-run symposium on November 16th. We are hoping this event will be a fun, low stress opportunity to share your research and practice your presentation skills.

The event will consist of a series of short 12-minute talks followed by a poster session with food and drink. Additionally, in an effort to create a little competition, we're inviting a few faculty members to serve as judges and will award prizes for the 'best' presentations and posters.

This is our 2nd annual research day and we need everyone's participation to make this a success. Please encourage your fellow students as well as your advisors to participate/attend the event. This event is open to all STEM grad students.

Submit a short abstract (200 words or less) to bmegsa@unm.edu about your research by October 26th. Everyone will have the opportunity to present a research poster but please indicate if you would like to give a short talk. The abstract template is attached to this email.

We encourage you to use abstracts/posters/presentations already prepared for other conferences, although please keep in mind your audience for this event. If you need assistance in printing a poster, please let us know.

We appreciate your support and look forward to hearing from you.

Thank you!
Your NSMS and BME GSA

"Understanding Cell Behavior through Single Cell and Single Molecule Biology", January 10-12, 2013

The CNTC will be a primary sponsor for a 3 day symposium and conference January 10-12, 2013 on "Understanding Cell Behavior through Single Cell and Single Molecule Imaging". Space is limited. CNTC members and trainees are encouraged to register and submit poster abstracts as soon as possible in order to guarantee a place. Information is at http://stmc.health.unm.edu/understanding-cell-behavior-through-single-cell-and-single-molecule-biology/index.html

A CINT grant to CNTC postdoc, Nesia Zurek

CNTC postdoc Nesia Zurek, was awarded a one year (10/2012-10/2013) CINT user grant titled "Biomimetic systems for studying membrane proteins." This award, in collaboration with her faculty advisors Drs. Andrew Shreve and Steven Graves from UNM and Dr. Gabriel Montano from LANL, provides access to facilities, equipment, and expertise at CINT for her project focused on determining if double cushioned membrane bilayers placed on polystyrene microspheres (hydrophobic) are fluid by FRAP experiments.

Joint CNTC/NSMS/CBME seminar, Wednesday October 03, 2012

Dr. James Castracane, Professor and Head of the Nanobioscience Constellation at the College of Nanoscale Science and Engineering (CNSE) of SUNY Albany, and Director of the New York State Center for Advanced Technology in Nanomaterials and Nanoelectronics (CATN2), will speak in the CBME seminar series at 4:00 PM on October 3rd in the Centennial Engineering building. Professor Castracane's research interests encompass fundamental materials science, nanobioscience, optoelectronics, MEMS, nanobioscience device development and applications of materials science to cancer.

Download Castracane biosketch pdf icon
Download Castracane abstract pdf icon

REMINDER: CINT Fall 2012 Call for Proposals is OPEN!!

User Proposal Submission: https://cint.sandia.gov/
Submission Deadline: September 30, 2012

Nanoscale Science Research Centers workshop

CNTC mentors Jennifer Martinez (CINT at LANL) and Dale Huber (CINT at SNL) will speak at the Joint NSRC Workshop on Nanoparticle Science at Argonne National Laboratory on November 5-6, 2012. Th workshop will focus on the synthesis, assembly and characterization of nanoparticles. CNTC students with CINT mentors are encouraged to submit posters to Dr. Gary Grest (ggrest@sandia.gov) by October 1. Details are at http://nano.anl.gov/docs/2012_nanoparticle_workshop_agenda.pdf pdf icon

Fluorescence Microscopy Shared Resource featured in the Cancer Center's Summer 2012 Shared Resources newsletter

CNTC mentors established and continue to lead the UNM Cancer Center's Fluorescence Microscopy Shared Resource.

The Summer 2012 Shared Resources newsletter focuses on instrumentation and technical expertise currently offered in the microscopy core. Complementing the fee-for service core, next generation imaging is offered through the STMC Super-resolution Imaging core.

CNTC mentor Jeremy Edwards featured in the September 09 Albuquerque Journal

Selecting the right drugs for targeted delivery to cancer requires information about the mutations leading to the cancer. CNTC mentor Jeremy Edwards has contributed to the development of new technology for fast, efficient DNA sequencing.

His lab will be among the first to receive the new Ion proton Genome Sequencer that incorporates this technology into an instrument that allows whole genome sequencing for cancer patients. The Edwards sequencing team includes CNTC postdoc Hazel Higgins.

Read the article pdf icon

New NIH grant to CNTC mentors Keith Lidke and Conrad James

August 2012. CTNC mentors Keith Lidke, Physics, and Conrad James, Sandia National Labs, have received a 3 year R21 grant from NIGMS. Grant R21GM104691 "Reflected Beam Illumination Microscopy using a Microfluidics Device" integrates microtechnology with superresolution imaging for a more detailed understanding of cell structure and function. This is the second new grant for CNTC mentors involved in cutting-edge microfluidics device design and development (see news item below about the new grant to CNTC mentor A. Singh).

The August 2012 Integrated Circuit newsletter

The Integrated Circuit is a newsletter from the Center for Integrated Nanotechnologies (CINT)

In this Issue:

  • A note from the UEC Chair, Linda Peteanu
  • 2012 CINT User Conference Information
  • User Executive Committee (UEC) Election Results
  • 2012A Call for Proposal Statistics
  • CINT Job Openings
  • New Capability: Nanoink Dip-Pen Nanolithography
  • Science Highlight: Ultrafast carrier dynamics and radiative recombination in multiferroic BiFeO3

Download the August 2012 Integrated Circuit newsletter pdf icon

New NCI grant to CNTC mentors Ness and Edwards

August 2012. CNTC mentors Scott Ness and Jeremy Edwards have been awarded a 5 year NCI grant in the highly competitive Provocative Questions program. Grant RO1 CA170250 "Alternative RNA splicing and protein products in leukemia outcome" will apply nano- and microtechnologies to radically improve the analysis of RNA products and of protein modifications associated with cancer.

New NIH funding for CNTC mentor Anup Singh

August 2012. Dr. Anup Singh, a leading expert at Sandia National Labs in the design and development of microfluidics devices, has been awarded a 5 year RO1 grant from NIAID. Grant R01AI098853 "Microfluidic Platform for Multiplexed Diagnostics" will support continued research on platform technologies for rapid and sensitive detection of biomarkers for infectious diseases and cancer.

LRRI SEMINAR SERIES Monday June 18, 12:00 PM

Heidi M. Mansour, Ph.D., R.Ph., will present "Advances in Targeted Lung Nanomedicine as Aerosolized Multifunctional Microparticles and Nanoparticles for Pulmonary Disease Treatment and Prevention" at the Lovelace Respiratory Research Institute in the American Home Auditorium. Dr. Mansour is Assistant Professor of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, and Faculty Associate, Center of Membrane Sciences, University of Kentucky. She is the guest of Dr. Steven A. Belinsky. Web conferencing options are available and those interested should contact Frances Laur at 505-348-9361 or via e-mail at flaur@lrri.org. For those interested in attending in person, please contact the front desk at 505-348-9400 to make arrangements for your visit and expedite the check-in process.

CNTC mentor Diane Lidke elected to the CINT Users Executive Committee

The Center for Integrated Nanotechnologies is a DOE-funded national user facility devoted to collaborative research on the design, performance and integration of nanoscale materials, including nanophotonic and optical nanomaterials and bio-mimetic nanosystems. CINT has user facilities at both the Los Alamos and Sandia National Laboratories. The UEC serves as a liaison between the user community and Center management and is the primary feedback mechanism by which the Department of Energy assesses the value of CINT facilities to the scientific community.

CNTC mentors Drs. Laurie Hudson and Angela Wandinger-Ness to receive three year $527, 661 DOD award to conduct Clinical Trial entitled: "Inhibition of small GTPases as a novel therapeutic approach in ovarian cancer."

Drs. Hudson and Wandinger-Ness identified the R-enantiomer of the nonsteroidal anti-inflammatory drug (NSAID) naproxen as a potential therapy to inhibit ovarian cancer cell metastasis. They determined that R-naproxen and the follow-up hit ketorolac were regulating the activation of Rac1 and Cdc42 small GTPases, suggesting a novel therapeutic ovarian cancer drug target. Having completed cell-based and preclinical animal studies, current work, in collaboration with Dr. Carolyn Muller, Director of the Division of Gynecological Oncology at the UNM Cancer Center, is focused on performing a pilot clinical trial of ketorolac in patients. The discovery phase of the project was performed in the UNM Center for Molecular Discovery, a specialty Center for high throughput flow cytometry-based screening of drug libraries against new therapeutic targets. The multiplexed bead-based screening strategy is illustrated in this slide pdf icon.

New CNTC fellows for June 01, 2012

Two postdocs and five graduate students have been awarded CNTC Fellowships beginning June 01, 2012. They are:

picture of Robert Taylor

Robert Taylor, Postdoctoral Fellow, Biochemistry
Mentors: Laurel Sillerud and Marco Bisoffi, Biochemistry and Molecular Biology and Dale Huber, CINT, SNL

"Therapy and magnetic resonance imaging of breast cancer metastases using blood brain barrier permeable, multi-targeted, multifunctional, iron platinum, crosslinked-stealth immunomicelles"

picture of Nesia Zurek

Nesia Zurek, Postdoctoral Fellow, Center for Biomedical Engineering
Mentors: Andrew Shreve, Center for Biomedical Engineering, Stephen Graves, Center for Biomedical Engineering and Paul McGuire, Cell Biology and Physiology

"High-throughput nanoscale biomimetic MMP assay for understanding cancer metastasis"

picture of Jacqueline A. De Lora

Jacqueline A. De Lora, Biomedical Sciences Graduate Program
Mentors: James Freyer, ChNE and Biomedical Engineering, Andrew Shreve, ChNE and Biomedical Engineering, Diane Lidke, Pathology

"Smart Nanosensors in 3D Cell Culture Systems for Characterization of the Tumor Microenvironment"

picture of Sebastian Godoy

Sebastian Godoy, Electrical and Computer Engineering Graduate Program
Mentors: Sanjay Krishna, ECE, Majeed Hayat, ECE and Marianne Berwick, Internal Medicine

"Non-invasive diagnostic imaging tool for skin cancer malignant lesion detection"

picture of Patrick Johnson

Patrick Johnson, Nanoscience and Microsystems Graduate Program
Mentors: Jeffrey Brinker, Chemical and Nuclear Engineering and Graham Timmins, Pharmacy

"Lipid/silica nano-bio-materials as a model for dormancy in tumor cells"

picture of  Jingshu Zhu

Jingshu Zhu, Nanoscience and Microsystems Graduate Program
Mentors: Steven Graves, Center for Biomedical Engineering and Bruce Edwards, Pathology

"Enzymatic Reactions on Nanospheres for High-throughput Screening"

UNM Cancer Center's Spring 2012 Newsletter highlights the role of nanoscience in cancer research in New Mexico

View the UNM Cancer Center's Spring 2012 Newsletter

Gates Foundation grant awarded to CNTC Mentor Pavan Muttil

Pavan has received a Gates Foundation Grand Challenges Exploration Award for research on "Pulmonary BCG Immunization for Uniform Protection Against Tuberculosis". The goal is to use dry powder carriers to deliver live BCG vaccine into the lungs, thereby maximizing the immune response in animals. A similar technology consisting of magnetic nanoparticles in dry powder carriers will enable improved delivery of anti-cancer drugs into the lungs. For more information see Grand Challenges in Global Health

Recognition for UNM's Center for Molecular Discovery

The success of nanoparticle-enabled drug delivery for improved outcomes in cancer depends on the carriers, the targeting strategy and the efficacy of the drugs once they are released at target sites. Scientists in UNM's Center for Molecular Discovery, led by CNTC mentor Larry Sklar, focus on the discovery of more effective anti-cancer drugs through screening already-approved drugs against cancer targets. Incorporating already-approved drugs into nanocarriers should greatly reduce the lead time from drug discovery to clinical use. An article in the May 14, 2012 edition of the Albuquerque Journal highlights the repurposing program in the Molecular Discovery Center pdf icon.

More detail can be found in a recent paper "Drug repurposing from an academic perspective" published in Drug Discovery Today: Therapeutic Strategies 8:61-69. As well as Dr. Sklar, authors include CNTC mentors T. Oprea, T. Buranda, B. Edwards, A. Wandinger-Ness and C. Willman.

June 05, 2012: CINT Day

All CNTC Fellows and Mentors are encouraged to participate in CINT day, June 5, 2012 from 1:30 to 3:30 pm. The goal is for all CNTC investigators to know about the resources available at CINT, to talk to CINT scientists about collaborative projects and to become familiar with the Rapid Access Proposal system that can provide funding for collaborative research.

Please note that advance registration is required. The first step to email Annette Mares-Duran (reu@unm.edu) to reserve a spot on this tour. The second step is to fill out and return to Annette the form that needs to be filled in to gain access to CINT. There are separate forms for US citizens and non-citizens. In view of DOE rules for access, it is imperative that all non-citizens submit these forms right away. Information on transportation and badge pickup will follow.

CNTC Retreat June 06

A CNTC retreat is planned for June 6, 2012 from 11:30 to 3:30 in the UNMCC auditorium. The goal is to provide a status update on the CNTC fellowship program, some highlights of recent research, and to make plans for the near term. A highlight of the program will be lightning talks from all of the CNTC Fellows. All current CNTC mentors and fellows are expected to attend. Potential CNTC mentors and fellows are cordially invited to join us.

Lunch will be served. More details will follow.

CNTC graduate fellow Robert Taylor is now Dr. Taylor

Robert successfully defended his thesis focused on novel NP-based imaging in prostate cancer on April 5. He is now a CNTC postdoc working on therapy and MRI imaging of breast cancer metastases using novel iron platinum immunomicelles. Congratulations to our first CNTC graduate!

CNTC mentor Diane S. Lidke has been awarded a $1.4 million NIH RO1 grant

April 2012. Titled "Sigle Molecule Imaging to Quantify FcεRI Signaling Dynamics," the new 5 year award from NIGMS integrates multiple imaging modalities, both novel and established, to capture and quantify the sequence, lifetime and subcellular localization of protein interactions that govern signal initiation. Collaborators on the project include Dr. Keith Lidke, Assistant Professor of Physics, Dr. Bridget Wilson, Professor of Pathology and Dr. Marcel Bruchez from Carnegie Mellon University.

A Human Frontier Science Program Grant has been awarded to CNTC mentor Diane S. Lidke and an international team

April, 2012. Dr. Diane S. Lidke, Assistant Professor of Pathology, and three international collaborators have been awarded a HFSP Program Grant of over $1.3 million. Research Grants provided by HFSP support basic research in the life sciences with emphasis on novel, innovative and interdisciplinary approaches that involve scientific exchanges across national and disciplinary boundaries. The three year project entitled "Nano-Mechano-Biology: spatiotemporal remodeling of membrane nanoplatforms under mechanical forces" is in collaboration with Dr. Alessandra Cambi from the Nijmegen Centre for Molecular Life Sciences (Nijmegen, the Netherlands), Dr. Maria Garcia-Parajo from the Institute of Photonic Sciences (Barcelona, Spain) and Dr. Satyajit Mayor from the National Centre for Biological Sciences (Bangalore, India).

As they circulate, cells of the immune system experience a large range of mechanical stimuli: from shear stresses encountered in blood flow and lymph nodes to irregular topographical cues of extracellular matrix fibers and changes in tension during movement from capillaries to tissue. The Lidke team will exploit cutting-edge biophysical tools, including superresolution and hyperspectral imaging, nanospectroscopy and novel microfluidics devices to explore how mechanical stress alters membrane protein organization and signaling at the molecular level.

Of the 800 pre-proposals submitted, only 68 were accepted as full proposals and eventually 25 were granted. The application by Lidke and collaborators was ranked number one.

UNM Cancer Center launches its Shared Resources newsletter

The first issue focuses on the Keck-UNM Genomics Resource (KUGR) that provides expertise and instrumentation for generating and analyzing the data from all types of gene expression and genomic analyses including microarrays, real-time PCR and Ion Torrent-based next-generation sequencing. Read the first issue.

2012 CINT Users Conference

Save the date for the next CINT Users Conference. The Conference is being held in Albuquerque, NM on September 19 & 20, 2012.

CNTC leader Elaine L. Bearer part of the 41st John Donald Robb Composers' Symposium

There will be a concert/dance performance featuring music by Dr. Bearer on Saturday, March 24 at 7:30 PM in Keller Hall at the University of New Mexico. Below are links to program notes and flyers provided by Dr. Bearer and the John Donald Robb Composers' Symposium.

Program Notes for March 24, 2012 pdf icon
Elaine L. Bearer flyer for March 24, 2012 pdf icon
41st John Donald Robb Composers' Symposium poster pdf icon

CNTC mentor Eva Chi receives a NSF Career Award

Dr. Chi is Assistant Professor in the UNM Center for Biomedical Engineering and the Department of Chemical and Nuclear Engineering. Details of the award can be found here: http://nsf.gov/awardsearch/showAward.do?AwardNumber=1150855

Spring 2012 – CINT Call for User Proposals

User Proposal Submission: https://cint.sandia.gov/
Website available: March 1, 2012
Submission Deadline: March 31, 2012

The Center for Integrated Nanotechnologies (CINT) is a Department of Energy, Office of Science Nanoscale Science Research Center jointly operated by Los Alamos and Sandia National Laboratories. As a National user facility, CINT provides access to its staff and capabilities for nanoscale science research at no fee to approved users for non-proprietary research. Proprietary research may be conducted under a full-cost recovery agreement.

Individuals and teams from industry, academia, and government institutions are invited to submit proposals to conduct research at CINT. Foreign National users can work at CINT if their visit is planned with sufficient lead-time. Prospective users should visit the CINT website (http://cint.lanl.gov) to learn about the technical staff, capabilities, and science thrusts prior to preparing a user proposal.

Updates on activities in the Center for Integrated Nanotechnologies (CINT)

CINT, the DoE-funded user facility for nanotechnologies at Sandia and Los Alamos National Labs, has launched a newsletter, Integrated Circuit, to share announcements, reminders, science highlights, and new capabilities with the User Community. CNTC students and mentors are encouraged to read the inaugural issue for opportunities to collaborate with the CINT community.
Download the February 2012 newsletter pdf icon
Read the online version

CNTC mentors at the forefront of two powerful trends in drug development

The first is an increasing emphasis on drug repurposing — finding new uses for established drugs. This approach has the potential to trim development costs and shorten the time it takes to bring new therapies to patients who need them. The second trend is the newly prominent role universities are playing in drug discovery, a role that's being shaped by shifts in the pharmaceutical industry and new incentives from the National Institutes of Health. Full story: http://news.unm.edu/?p=24934

KNME's 'Connect' features CNTC mentor Jeffrey Brinker

This month, KNME's "Connect" features Jeffrey Brinker, UNM professor in Chemical and Nuclear Engineering, Molecular Genetics and Microbiology. On the cutting edge of materials science, Brinker is developing nanoscale materials for curing cancer, microelectronics and energy harvesting. Connect airs Thursday, Feb.16 at 7:00 PM on KNME 5.1 and Sunday, Feb. 19 at 5:00 PM on KNMD 9.1. Website: http://www.knme.org/connect/

The next CNTC application deadline is March 15, 2012

The New Mexico Cancer Nanotechnology Training Center (CNTC) provides stipends and interdisciplinary training to graduate students and postdocs whose interdisciplinary research uses nanoscience and nanoscience-enabled microsystems to understand the fundamental properties of cancer cells and to discover and develop diagnostic, prognostic and therapeutic tools with potential to reduce suffering and death due to cancer. Students may be enrolled in the Biomedical Sciences Graduate Program on the UNM North Campus or in any of the Physical Sciences and Engineering Programs, including NSMS, on South Campus. Support will be allocated based on the academic qualifications of the student and his/her advisors, the scientific merit of the project, and the likelihood that the fellowship will work as "glue" to enhance interactions between physical and biomedical scientists working at the interface of nanoscience and cancer. Fellowship support is for one year, renewable for a second year based on good progress. Tuition, fees and health insurance will be paid in addition to the stipend.

Applications from minorities and women are encouraged. Postdocs and students who are NOT US citizens MAY apply for these fellowships. CNTC fellows may work at UNM and at partnering institutions, including the Los Alamos and Sandia National Labs. The next CNTC application deadline is March 15 for students seeking fellowship support beginning June 1, 2012. For more information, please see How to Apply.

Cancer Nanotech among the key accomplishments of the UNM Center for High Tech Materials

An interview with long-time CHTM Director, Steve Brueck, highlights a new quantum dot-based IR camera developed for improved diagnosis of skin cancer. Read the interview at UNM Today

q-bio Summer School applications are now open

More information here: http://www.cvent.com/d/fUmM4tHqyEWWYFciYUFJuw/kjhd/P1/1Q?

January 2012 NCI Alliance Newsletter

Download the January 2012 NCI Alliance Newsletter pdf icon

The UNM Center for Biomedical Engineering has launched a new course in Good Manufacturing Practices

GMP is the critical step between basic research and clinical applications. CNTC students developing new nanoparticles for drug delivery and imaging are strongly encouraged to enroll.
More information and the syllabus is at http://cntc.unm.edu/other-relevant-courses.html
Download the course flier pdf icon

CNTC member Angela Wandinger-Ness writes about the importance and rewards of role models and mentoring

CNTC member Angela Wandinger-Ness writes about the importance and rewards of role models and mentoring in November 2011 ASCB Newsletter. Download the article pdf icon.

Alliance Challenge Projects due February 6, 2012

Each CCNE and CNPP has a fraction of budget restricted for collaborative "Alliance Challenge Projects". Although the CNTCs do not have setasides in their budgets, CNTC Fellows and their mentors may collaborate with a CCNE or CNTC to compete for these funds. Information is here pdf icon.

One of four "Technology Development for New Affinity Reagents Against the Human Proteome (U54)" grants awarded to CNTC mentor Andrew Bradbury

This new funding from the NIH Common Fund through the Office of the NIH Director will support the production of large numbers of recombinant high quality polyclonal antibodies from which monoclonal antibodies can subsequently be selected and engineered for greater affinity and specificity. Through its ability to generate tumor-specific antibodies, the award is expected to significantly increase the availability of targeting proteins for nanotherapeutics.

NCI site-visit Practice Presentations: November 11, 2011

NCI site-visit Practice Presentations are on Friday, November 11, 2011 from 1:00 - 3:00 PM at the UNMCC Auditorium. Traineess and students are all strongly encouraged to attend.

Note: the NCI site visit will be on November 17 from 1:00 - 5:00 PM in the UNM Cancer Center's auditorium. Attendance is required of all CNTC leaders, current and former fellows and current mentors.

This will be an educational meeting as well as a review of the program. Students considering an application to be CNTC fellows as well as faculty who would like to mentor a future CNTC fellow are cordially invited to attend.

The agenda will include:

  • 1-1:15: Introductions
  • 1:15-1:45: PI overview
  • 1:45-3:45: Student presentations and roundtable discussion with the NCI review team
  • 3:45-4:05: NCI presentation
  • 4:15-5:00: Executive session

Box lunches will be available at 12:30 pm - send an RSVP to Liz Torrez (metorrez@salud.unm.edu) before noon on Monday November 14 if you would like to be on the list for a light lunch.

Note that parking is available in the lot just west of the Cancer Center building. See map pdf icon

Nanotools and super-resolution imaging reveal new details of ErbB1 dimerization

CNTC mentors faculty Diane Lidke (Pathology) and Keith Lidke (Physics) have pioneered applications of quantum dot nanoprobes and live cell imaging to explore the dynamic properties of ErbB receptors implicated in multiple cancers. Their new paper in Nature Structural and Molecular Biology, collaborative with Bridget Wilson (Pathology), reports the first direct evidence for the transient co-confinement of ErbB1 molecules on the membranes of epithelial cells in the absence of ligand. They also provide the first real time measurement of EGF-mediated ErbB1 dimerization kinetics and the first evidence that kinase inhibitors can modulate receptor dynamics. The first author, Shalini Low-Nam, was supported by the NCI-co-funded NSMS IGERT grant, the precursor to the CNTC program. Another former IGERT student, Patrick Cutler, is a co-author.
Download the article pdf icon.

Seminar: "Introduction to post-doctoral fellowship applications"

CNTC graduate students and postdocs are encouraged to attend a two-session seminar, "Introduction to post-doctoral fellowship applications".

Seminar Director: Dr. Laurie Hudson, Professor of Pharmacy
Dates: 10/25 from 12:00 - 2:00 PM and 11/22 from 12:00 - 2:00 PM
Place: Domenici CW 2112

Topics to be covered:

  • Identifying funding opportunities
  • Assessing needs for a strong application (preliminary findings, resources, mentoring committee, etc.)
  • Fellowship sections
  • Review criteria and the review process
  • Tips and traps

The seminar is sponsored by the UNM HSC Postdoc Association.

New Mexico CNTC is featured in the 2011 NCI Alliance for Nanotechnology in Cancer Annual Bulletin

See the new Bulletin for an article featuring science from the Brinker lab and other news from our center. Download the 2011 NCI Alliance for Nanotechnology in Cancer Annual Bulletin pdf icon

CNTC mentor Angela Wandinger-Ness will spend Oct-Nov, 2011 at the Max-Planck Institute for Molecular Physiology

Her visit was hosted by Dr. Roger Goody and funded by a DAAD Visiting Professorship Award.

CINT Call for Proposals ends September 30

The Center for Integrated Nanotechnologies (CINT) is a Department of Energy, Basic Energy Sciences Nanoscale Science Research Center jointly operated by Los Alamos and Sandia National Laboratories. As a National user facility, CINT provides access to its staff and capabilities for nanoscale science research at no fee to approved users for non-proprietary research. Proprietary research may be conducted under a full-cost recovery agreement.

For more details, visit CINT Fall 2011 - Call for user Proposals.

2011 CINT User Conference

Los Alamos National Laboratory and Sandia National Laboratories, in coordination with the New Mexico Consortium, will host the 2011 CINT User Conference on September 14-16 at the Marriott Pyramid North Hotel in Albuquerque, New Mexico.

CNTC mentor Diane Lidke will speak at the conference on Using Quantum Dots to Track Membrane Protein Dynamics in Living Cells.

For more information see https://cint.newmexicoconsortium.org/

UNM Nanoscale Materials and Nanomedicine Laboratory Grand Opening

The lab will serve as interdisciplinary center to fabricate and test new nanoscale materials to better understand, diagnose, and treat cancer and other diseases. It combines state-of-the-art fabrication capabilities with optical and scanning probe imaging and cellular biology.

For more information: New Research Facility Celebrates Grand Opening in the School of Engineering

STMC PI Janet Oliver is named the Frederick H. Harvey III Chair of Pathology

Established by the Harvey Family, the Harvey Chair recognizes faculty who lead innovative translational research.

Announcing the CNTC Fellows for Fall 2011

Two graduate students and two postdoctoral fellow will receive CNTC fellowships beginning August 01, 2011.

They are:

Hazel Higgins, PhD, School of Medicine and Cancer Center
Mentor: Jeremy Edwards, Molecular Genetics and Chemical Engineering
"Nanotechnology Genomics Tools to Study the Microscale Evolution and Adaptation of Cancer Cells."
picture of Mara Steinkamp Mara Steinkamp, PhD, School of Medicine and Cancer Center
Mentor: Bridget Wilson, Pathology
"ErbB3 Signaling: Single Particle Tracking and Intravital Imaging to Probe ErbB3 Interactions and Potential as a Therapeutic Target for Ovarian Cancer."
picture of Dominic Maes Dominic Maes, Nanoscience and Microsystems Graduate Program
Mentors: Shuang Luan, Computer Science, Donna Sierjiej, Medical Physics and Philip Heintz, Radiology
"Fast Dose Calculations for Particle Radiation Therapy using Cloud Computing."
picture of Robert Taylor Robert M. Taylor, Biomedical Sciences Graduate Program
Mentors: Laurel Sillerud and Marco Bisoffi, Biochemistry and Molecular Biology, and Dale Huber, Sandia National Labs, Center for Integrated Nanotechnologies
"Multifunctional Iron Platinum Stealth Immunomicelles: Targeted Detection and Therapy of Human Prostate Cancer Cells using both Fluorescence and Magnetic Resonance Imaging."

August ACSB Newsletter highlights UNM Academic Science, Education and Research Training program led by CNTC mentor Angela Wandinger-Ness

The August edition of the ACSB Newsletter highlights the UNM Academic Science, Education and Research Training program for postdoctoral fellows led by CNTC mentor Angela Wandinger-Ness. ASERT can support CNTC postdocs wishing to achieve excellence as both educators and research scientists. Download the articlepdf icon

Biophysics at the Cutting Edge: A Report from the 55th Annual Meeting of the Biophysical Society

Diane Lidke's work with Shalini Low-Nam and Bridget Wilson using 2 colors of quantum dote to quantify the motions of EGFR monomers and formation of dimers was highlighted in a new review by Prithwish Pal. Download the review pdf icon

Brinker team's porous nanoparticles hailed by NCI

Brinker team's porous nanoparticles hailed by NCI in the May 2011 issue of Nano.Cancer.Gov News. Read the full story in NCI's Nanotech News . The Brinker team's work on protocell technology was also featured in the June 2011 issue of the NCI Alliance newsletter.

UNM Today features CNTC mentor Ed Flynn

Edward Flynn and colleagues at the UNM Cancer Center are using magnetic nanoparticles and SQUID imaging to detect breast cancer cells earlier. Read more

CNTC mentor & UNM Cancer Center genomics core co-leader Jeremy Edwards recognized for new genome sequencing technology

Edwards, Associate Professor of Molecular Genetics and Microbiology in the School of Medicine and of Chemical and Nuclear Engineering in the School of Engineering, has pioneered the development of microfluidics-based fast, inexpensive whole genome sequencing for personalized treatment for cancer. His work is supported by one of 10 $1,000 genome grants awarded recently by the NIH/National Human Genome Research Institute. A feature article appeared in the May 09, 2011 issue of the Albuquerque Journal. Read the article from the Albuquerque Journal pdf icon graphic

UNM Research Looks at Cancer

Read the article from the Albuquerque Journal pdf icon graphic

Larry Sklar Named STC.UNM Innovation Fellow for 2011

CNTC mentor Larry Sklar, Regents' Professor and Distinguished Professor in the Department of Pathology at UNM's School of Medicine, has been recognized as the 2011 STC.UNM Innovation Fellow. He was honored at the 8th Annual Creative Awards Reception on April 21, 2011. Read more

New CNTC Graduate Students and Fellows Named

Three graduate students and one postdoctoral fellow will receive CNTC fellowships beginning June 01, 2011.

They are:

Jie Lu, PhD, Postdoctoral Fellow, College of Pharmacy
Mentors Yubin Miao, Pharmacy and Eric Prossnitz, Cell Biology
"Development of GPCR-targeted imaging agents for cancer detection"
Paul Durfee, Nanoscience and Microsystems Graduate Program
Mentors Bryce Chakerian, Molecular Genetics and Microbiology and Jeffrey Brinker, Sandia/UNM Chemical and Nuclear Engineering
"Suppression of immune response to cancer-targeted drug delivery nanocarriers"
Yuna Guo, Biomedical Sciences Graduate Program Mentors Angela Wandinger-Ness, Pathology, Laurie Hudson, Pharmacy and Eric Carnes, Chemical and Nuclear Engineering
"Rac1 and cdc42 as novel targets for ovarian cancer therapy"
picture of Jason Rogers Jason Rogers, Biomedical Sciences Graduate Program Mentors Cheryl Willman and Walker Wharton, Pathology and Jeffrey Brinker, Sandia/UNM Chemical and Nuclear Engineering
"CD19-targeted nanoparticles"

Sandia and UNM lead effort to destroy cancers

Read the article from Sandia Labs News Releases

Brinker group's Protocell Paper published online at Nature Materials

nature materials coverNanoparticles capable of specifically binding to target cells and delivering high doses of therapeutic compounds are much sought after in materials science applied to medicine. The creation of a new class of nanoparticles, called protocells, to solve many challenges in nanotherapeutics is described in the Nature Materials advance online publication and News and Views commentary attached here. Led by Jeff Brinker from the UNM/Sandia joint Advanced Materials Lab, the research team includes recent UNM PhD graduates Carlee Ashley and Eric Carnes, current UNM graduate students Paul Durfee and Nick Carroll, and faculty and scientists from the UNM School of Engineering, the UNM Cancer Center and Sandia National Labs.

pdf icon graphic Read the Nature Materials paper
pdf icon graphic Read Nature Materials News and Views

The Art of Systems Biology and Nanoscience

The Art of Systems Biology and Nanoscience is coming to the Santa Fe Complex on April 1st and 2nd. Come explore some of the newest and most fascinating images from two emergent branches of science during this two-day public celebration. Learn more about the schedule of events, lectures, and exhibitions

CNTC Mentors in The Wall Street Journal

The Wall Street Journal recently reported on research by UNM Cancer Center scientist and CNTC mentor, Dr. Edward Flynn. Dr. Flynn and team are developing a new technology that could allow for the detection of HER-2 breast cancers up to 2½ years earlier than conventional mammography. The technology uses nanoparticles of iron oxide attached to certain antibodies and a magnetic coil device known as SQUID to help researchers detect and measure breast cancer cells. Read more

CNTC PI Janet Oliver elected an AAAS Fellow

Janet Oliver was elected a Fellow of the American Association for the Advancement of Science at the Fellows Forum held on 19 February 2011 during the AAAS Annual Meeting in Washington, D.C. AAAS Fellows are recognized for outstanding contributions to science and technology.

CNTC award recognized in the Cancer Letter

The February 18, 2011 issue of The Cancer Letter has a front page article on the New Mexico CNTC. The same issue recognizes CNTC mentor Larry Sklar for his recent election as a member of the American Institute for Medical and Biological Engineering College of Fellows. The College of Fellows consists of 1,000 individuals throughout the world who have shown excellence in bioengineering research, industrial practice, and/or education. Read the issue pdf icon graphic

CNTC Mentor Timlin describes the influence of NP geometry on NP-cell interaction

CNTC mentor Jerilyn Timlin and postdoc Jesse Aaron have used high speed TIRF microscopy to show that rod shaped QDs diffuse in membranes and are internalized more slowly than more spherical particles and that particle size affects localization within intracellular vesicles. Their paper was published in Small. 2011 Feb 7;7(3):334-41. Read the paper pdf icon graphic

CNTC mentor Diane Lidke to receive 2011 Margaret Oakley Dayhoff Award

CNTC mentor Diane Lidke will receive the 2011 Margaret Oakley Dayhoff Award from the Biophysical Society for her innovative work integrating the disciplines of biophysics, bioimaging and quantitative biology. The Award will be presented at the 2011 Annual Biophysical Society Meeting in Baltimore, Maryland, March 5-9, 2011.

Visit: The Biophysical Society's Margaret Oakley Dayhoff Award page

KOAT-TV Nanotechnology Story

This story aired on November 13, 2010.

UNM, Sandia land $4M in funding for nanotech cancer research

New Mexico Business Weekly November 11, 2010
The University of New Mexico’s Cancer Center and Sandia National Laboratories have received nearly $4 million in grants to research how nanotechnology can be used to prevent and treat cancer. The grants, awarded by the National Cancer Institute, will be used to build a 4,500-square-foot Cancer Nanotechnology Training Center on the UNM campus. Construction is scheduled to begin in December. Read more

National Cancer Institute Awards Nearly $4M to University of New Mexico Cancer Center to Support Cancer Nanotechnology Partnership with Sandia Labs

Newswise.com November 9, 2010
The National Cancer Institute recently announced two five-year awards totaling nearly $4 million for a partnership between the University of New Mexico Cancer Center and Sandia National Laboratories. One $1.95 million grant will fund the creation of a joint Cancer Nanotechnology Platform Partnership, and another $1.8 million grant will pay for a new Cancer Nanotechnology Training Center to train a new generation of multidisciplinary scientists. In addition, the state of New Mexico is providing another $2 million to build a lab supporting Sandia Fellow and UNM professor Jeff Brinker’s research, which is devoted to nano-bio materials and nanomedicine. UNM donated more than 4,500 square feet of lab space in the new Centennial Engineering Building for the project, and construction is scheduled to begin December 2010. Read more